Let Me Count The Reasons
Bill Maher ticks off some notions of why The Decider should get the boot:

America Deserves More Than A Change In Rhetoric

ITCS IX: The Grand Unified Theory of Republican Corruption
"Not looking too good for Rep. Rick Renzi (R-AZ) ... Renzi is the subject of a federal investigation centering on a shady land deal ... the New York Times ... were reporting an investigation into what appears to be an entirely separate bad act ... a piece of legislation Renzi introduced to help ... a telecom company that happens to employ Renzi's father ... the company in question is an intel contractor that apparently had ties to Mitch Wade's MZM. So if you're still looking for the grand unified theory of GOP corruption, hey, the night's still young."

ITCS VIII: GOP Will Do ANYTHING To Suppress Voter Turnout
"... The Los Angeles Times reported that Tan Nguyen, the Republican challenger in California's 47th District, was under investigation for attempted voter suppression ... The feds are probing Nguyen's campaign for sending a letter to approximately 15,000 Latino voters sometime in the last two weeks warning that 'if... you are an immigrant, voting in a federal election is a crime that could result in jail time.' The letter was made to appear as if it came from a local immigration reform group and was signed by an apparently fictional name. Today, the Times reports that, despite his categorial denials, Nguyen was personally involved in the mailing ..."

It's The Failure, Stupid
Josh nails it: "Think of the president as a failed or deadbeat entrepreneur (again, not such a stretch) who's already lost his investors a ton of money. He goes back to them and says, 'Okay, fine. You think I'm a moron and a screw-up who lost you guys a ton of money. Fine. But do you really want to finally, totally, conclusively kiss that $300 billion goodbye. You wanna just totally call it quits? Admit it's a total loss? What about giving me just another $10 billion and maybe somehow I'll actually pull this off? Or, since that's just not gonna happen, a mere $10 billion to put off for six months having to write the whole thing off as a loss, having to come to grips once and for all with the fact that all the money's gonna and the whole thing's a bust?'
That's really what this is about. And I think we all know it pretty much across the political spectrum. In this way, paradoxically, the very magnitude of the president's failure has become his tacit ally. It's just such a big thing to come to grips with..."

ITCS VII: No Bush Family Member Left Behind
"A company headed by President Bush's brother and partly owned by his parents is benefiting from Republican connections and federal dollars targeted for economically disadvantaged students under the No Child Left Behind Act. With investments from his parents, George H.W. and Barbara Bush, and other backers, Neil Bush's company, Ignite! Learning, has placed its products in 40 U.S. school districts and now plans to market internationally. ... Interviews and a review of school district documents obtained under the Freedom of Information Act found that educators and legal experts were sharply divided over whether Ignite's products were worth their cost or qualified under the No Child law."